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- drugbank:DB08831 type drugbank_vocabulary:Drug assertion.
- drugbank:DB08831 label "2-deoxyglucose [drugbank:DB08831]" assertion.
- drugbank:DB08831 seeAlso DB08831 assertion.
- drugbank:DB08831 description "2-deoxyglucose is predominantly used as a diagnostic agent in its radiolabelled form (fluorine-18 is used as the radiolabel). By using positron emission tomography (PET), radiolabelled 2-deoxyglucose can determine glucose metabolism, which is altered in diseases such as cardiovascular disease, tumors, and Alzheimer's disease. Therapeutically, 2-deoxyglucose is an investigational drug that is being studied as an anticancer and antiviral agent. Concerning the former, 2- deoxyglucose was used as an adjunct to chemotherapy and radiotherapy in the treatment of solid tumors (lung, breast, pancreas, head, neck, and gastric tumors). The exact mechanisms of action of 2-deoxyglucose is still being investigated, but it is known that in hypoxic cancer cells, 2-deoxyglucose is a glycolysis inhibitor that prevents ATP production and, ultimately, cell survival. With respect to antiviral therapy, 2-deoxyglucose was shown to be effective against herpes simplex virus by affecting the virus' ability to penetrate cells. As an experimental drug, 2-deoxyglucose was demonstrated to work as an anticonvulsant in temporal lobe epilepsy. In this condition, 2-deoxyglucose represses the expression of certain proteins that are at high levels after a seizure. Although there are several possible therapeutic indications for 2-deoxyglucose, presently there is no approved indication for 2-deoxyglucose as a therapeutic agent." assertion.
- drugbank:DB08831 identifier "drugbank:DB08831" assertion.
- drugbank:DB08831 title "2-deoxyglucose" assertion.
- drugbank:DB08831 drugbank_vocabulary:x-cas cas:154-17-6 assertion.
- drugbank:DB08831 drugbank_vocabulary:drugbank-id "DB08831" assertion.
- drugbank:DB08831 bio2rdf_vocabulary:x-identifiers.org DB08831 assertion.
- drugbank:DB08831 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB08831" assertion.
- drugbank:DB08831 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB08831 bio2rdf_vocabulary:identifier "DB08831" assertion.
- drugbank:DB08831 drugbank_vocabulary:x-wikipedia wikipedia:2-Deoxy-D-glucose assertion.
- drugbank:DB08831 drugbank_vocabulary:x-kegg kegg:C00586 assertion.
- drugbank:DB08831 drugbank_vocabulary:x-chebi chebi:15866 assertion.