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- NP228241.RAu-KyNdD6sh1il0S30gtsNYKoepBncXWAYmR2FwthF2U130_assertion type Assertion NP228241.RAu-KyNdD6sh1il0S30gtsNYKoepBncXWAYmR2FwthF2U130_head.
- NP228241.RAu-KyNdD6sh1il0S30gtsNYKoepBncXWAYmR2FwthF2U130_assertion wasGeneratedBy ECO_0000203 NP228241.RAu-KyNdD6sh1il0S30gtsNYKoepBncXWAYmR2FwthF2U130_provenance.
- NP228241.RAu-KyNdD6sh1il0S30gtsNYKoepBncXWAYmR2FwthF2U130_assertion wasDerivedFrom befree-20140225 NP228241.RAu-KyNdD6sh1il0S30gtsNYKoepBncXWAYmR2FwthF2U130_provenance.
- NP228241.RAu-KyNdD6sh1il0S30gtsNYKoepBncXWAYmR2FwthF2U130_assertion SIO_000772 15724245 NP228241.RAu-KyNdD6sh1il0S30gtsNYKoepBncXWAYmR2FwthF2U130_provenance.
- NP228241.RAu-KyNdD6sh1il0S30gtsNYKoepBncXWAYmR2FwthF2U130_assertion evidence source_evidence_literature NP228241.RAu-KyNdD6sh1il0S30gtsNYKoepBncXWAYmR2FwthF2U130_provenance.
- NP228241.RAu-KyNdD6sh1il0S30gtsNYKoepBncXWAYmR2FwthF2U130_assertion description "[We investigated the roles of Toll-like receptor 2 (TLR2) and myeloid differentiation factor 88 (MyD88) in the course of a lymphocytic choriomeningitis virus (LCMV) infection and revealed the following: (i) studies of transfected cells and murine peritoneal macrophages demonstrated that TLR2 and MyD88 are essential for the initial pro-inflammatory cytokine response (human IL-8, mouse IL-6) to LCMV; (ii) TLR2 knockout (KO) mice and MyD88 KO mice challenged with LCMV produced less IL-6 and monocyte chemotactic protein-1 in the serum than wild-type mice; (iii) in contrast to inflammatory cytokines, the production of type 1 IFN (IFN-alpha) in response to LCMV was MyD88 independent; (iv) MyD88 plays an essential role in antiviral CD8(+) T cell responses, CD8(+) T cells in MyD88 KO mice were defective in their expression of intracellular antiviral cytokines; and (v) the failure of MyD88 KO mice to activate CD8(+) T cells was accompanied by persistent viral infection in MyD88 KO mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP228241.RAu-KyNdD6sh1il0S30gtsNYKoepBncXWAYmR2FwthF2U130_provenance.