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- NP437452.RA1SU7pBk3a3TwcabkPVurSdfqAPF-uP_BzbiO83vq9_c130_assertion type Assertion NP437452.RA1SU7pBk3a3TwcabkPVurSdfqAPF-uP_BzbiO83vq9_c130_head.
- NP437452.RA1SU7pBk3a3TwcabkPVurSdfqAPF-uP_BzbiO83vq9_c130_assertion wasGeneratedBy ECO_0000203 NP437452.RA1SU7pBk3a3TwcabkPVurSdfqAPF-uP_BzbiO83vq9_c130_provenance.
- NP437452.RA1SU7pBk3a3TwcabkPVurSdfqAPF-uP_BzbiO83vq9_c130_assertion wasDerivedFrom befree-20150227 NP437452.RA1SU7pBk3a3TwcabkPVurSdfqAPF-uP_BzbiO83vq9_c130_provenance.
- NP437452.RA1SU7pBk3a3TwcabkPVurSdfqAPF-uP_BzbiO83vq9_c130_assertion SIO_000772 16949064 NP437452.RA1SU7pBk3a3TwcabkPVurSdfqAPF-uP_BzbiO83vq9_c130_provenance.
- NP437452.RA1SU7pBk3a3TwcabkPVurSdfqAPF-uP_BzbiO83vq9_c130_assertion evidence source_evidence_literature NP437452.RA1SU7pBk3a3TwcabkPVurSdfqAPF-uP_BzbiO83vq9_c130_provenance.
- NP437452.RA1SU7pBk3a3TwcabkPVurSdfqAPF-uP_BzbiO83vq9_c130_assertion description "[The initial study found that urine concentrations of the metabolites 1,2-dihydroxy-4-(acetyl) butane (M1) and 1-dihydroxy-2-(N-acetylcysteinyl)-3-butene (M2) and blood concentrations of the hemoglobin adducts N-[2-hydroxy-3-butenyl] valine (HB-Val) and N-[2,3,4-trihydroxy-butyl] valine (THB-Val) constitute excellent biomarkers of exposure, both being highly correlated with BD exposure levels, and that GST genotypes modulate at least one metabolic pathway, but that irreversible genotoxic effects such as chromosome aberrations and HPRT gene mutations are neither associated with BD exposure levels nor with worker genotypes (GST [glutathione-S-transferase]-M1, GSTT1, CYP2E1 (5' promoter), CYP2E1 (intron 6), EH [epoxide hydrolase] 113, EH139, ADH [alcohol dehydrogenase]2 and ADH3).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP437452.RA1SU7pBk3a3TwcabkPVurSdfqAPF-uP_BzbiO83vq9_c130_provenance.