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- assertion wasGeneratedBy ECO_0000203 provenance.
- assertion wasDerivedFrom BEFREE provenance.
- assertion SIO_000772 22447927 provenance.
- assertion evidence source_evidence_literature provenance.
- assertion description "[We conclude that polymorphisms within the NOD Ica1 core promoter may determine AIRE-mediated down-regulation of ICA69 expression in medullary thymic epithelial cells, thus providing a novel mechanistic explanation for the loss of immunologic tolerance to this self-antigen in autoimmunity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." provenance.