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- NP987916.RAWW3nxy2YKieBYujOqwYiW89QUJgjNRSiqLEsDuABNxg130_assertion type Assertion NP987916.RAWW3nxy2YKieBYujOqwYiW89QUJgjNRSiqLEsDuABNxg130_head.
- NP987916.RAWW3nxy2YKieBYujOqwYiW89QUJgjNRSiqLEsDuABNxg130_assertion wasGeneratedBy ECO_0000203 NP987916.RAWW3nxy2YKieBYujOqwYiW89QUJgjNRSiqLEsDuABNxg130_provenance.
- NP987916.RAWW3nxy2YKieBYujOqwYiW89QUJgjNRSiqLEsDuABNxg130_assertion wasDerivedFrom befree-20150227 NP987916.RAWW3nxy2YKieBYujOqwYiW89QUJgjNRSiqLEsDuABNxg130_provenance.
- NP987916.RAWW3nxy2YKieBYujOqwYiW89QUJgjNRSiqLEsDuABNxg130_assertion SIO_000772 16949064 NP987916.RAWW3nxy2YKieBYujOqwYiW89QUJgjNRSiqLEsDuABNxg130_provenance.
- NP987916.RAWW3nxy2YKieBYujOqwYiW89QUJgjNRSiqLEsDuABNxg130_assertion evidence source_evidence_literature NP987916.RAWW3nxy2YKieBYujOqwYiW89QUJgjNRSiqLEsDuABNxg130_provenance.
- NP987916.RAWW3nxy2YKieBYujOqwYiW89QUJgjNRSiqLEsDuABNxg130_assertion description "[The initial study found that urine concentrations of the metabolites 1,2-dihydroxy-4-(acetyl) butane (M1) and 1-dihydroxy-2-(N-acetylcysteinyl)-3-butene (M2) and blood concentrations of the hemoglobin adducts N-[2-hydroxy-3-butenyl] valine (HB-Val) and N-[2,3,4-trihydroxy-butyl] valine (THB-Val) constitute excellent biomarkers of exposure, both being highly correlated with BD exposure levels, and that GST genotypes modulate at least one metabolic pathway, but that irreversible genotoxic effects such as chromosome aberrations and HPRT gene mutations are neither associated with BD exposure levels nor with worker genotypes (GST [glutathione-S-transferase]-M1, GSTT1, CYP2E1 (5' promoter), CYP2E1 (intron 6), EH [epoxide hydrolase] 113, EH139, ADH [alcohol dehydrogenase]2 and ADH3).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP987916.RAWW3nxy2YKieBYujOqwYiW89QUJgjNRSiqLEsDuABNxg130_provenance.