Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RA-C_vCKe2iN2qoydo4AbCdCp2COYirSHsGrg1aVz0NTg#_5> ?p ?o ?g. }
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- _5 wasQuotedFrom 14985333 provenance.
- _5 value "Here we demonstrate that cyclin-dependent kinase 2 (CDK2) in association with cyclin A or cyclin E directly binds to beta-catenin. In vivo and in vitro kinase assays with cyclin-CDK2 demonstrate beta-catenin phosphorylation on residues Ser(33), Ser(37), Thr(41), and Ser(45). This phosphorylation promotes rapid degradation of cytosolic beta-catenin via the beta-TrCP-mediated proteasome pathway." provenance.