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- _6 wasQuotedFrom 18268343 provenance.
- _6 value "(from text) Furthermore, decreasing endogenous levels of FOXO3a protein by siRNA increases HIF-1 transcriptional activity in PTEN-positive HEK-293 cells (Fig. 6Fig. 6. D and E). Collectively, our findings support the argument that FOXO3a is a negative regulator of HIF-1 transcriptional activity by interfering with the ability of p300 to serve a transcriptional coactivator." provenance.