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- _6 wasQuotedFrom 12776987 provenance.
- _6 value "Full text: SHB binds the activated FGFR-1 at tyrosine 766, which causes SRC-dependent tyrosine phosphorylation of SHB. SHB also associates constitutively to SHP-2, and upon FGF-2 stimulation, SHB/SHP-2 bridging promotes FRS-2 phosphorylation and activation. Thus, SHB is required for an adequate activation of the RAS/ERK pathway and endothelial cell cell mitogenesis [13]." provenance.