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- _5 wasQuotedFrom 11380688 provenance.
- _5 value "As male ER-�???�??�?�±�??�?�¢?? mice are known to have lower IGF-1 levels in serum,33,34 we propose that their smaller spleens are caused by suppressed activity in the GH/IGF-1 axis. In order to test directly the hypothetical importance of IGF-1 in oestrogen-mediated effects on male immune organ development, replacement studies with IGF-1 in ERKO mice are currently underway in our laboratory." provenance.