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- _5 wasQuotedFrom 18483355 provenance.
- _5 value "Studies to date suggest that, in these cancers, several (if not all) of the critical downstream signaling pathways, including the phosphoinositide 3-kinase (PI3K)/Akt, signal transducers and activators of transcription, and extracellular signal-regulated kinase 1 and 2 pathways, are solely controlled by EGFR. Thus, when the tumors are exposed to EGFR inhibitors, these intracellular pathways are turned off and the cancer cells undergo apoptosis (21, 22, 24, 25)." provenance.