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- _7 wasQuotedFrom 12891700 provenance.
- _7 value "Preformed Mac-1 is stored in granules in neutrophils and can be rapidly mobilized to the neutrophil surface after exposure to degranulation stimuli such as the bacterial peptide fMLP or to cytokines (Altieri and Edgington, 1988). However, it is not yet competent for ligand binding. The ligand binding site lies on an extracellular region of the α subunit called the I domain, that is inaccessible to potential ligands unless integrins are activated. Integrin activation involves a conformational change such that the I domain is exposed (Oxvig et al., 1999). This change may be induced by phosphorylation of the cytoplasmic tail of the β subunit (Buyon et al., 1997), possibly through a pathway involving the small GTP-binding protein Rho, but this is still unclear." provenance.