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- _8 wasQuotedFrom 11694526 provenance.
- _8 value "Pufa suppression of Srebf1c expression is mediated through its competition with Lxr ligand in the activation of the ligand binding domain of Lxr, thereby inhibiting binding of Lxr/retinoid X receptor heterodimer to the LXREs in the Srebf1c promoter Pufas could be deeply involved in nutritional regulation of cellular fatty acid levels by inhibiting an Lxr-Srebf1c system crucial for lipogenesis" provenance.