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- _5 wasQuotedFrom 11827174 provenance.
- _5 value "Response elements present in the promoter sequences of the human catalytic (CK2alpha) and regulatory (CK2beta) subunit genes have been examined for the significance in transcriptional control using reporter gene assays, electrophoretic mobility shift assays, site-directed mutagenesis, ectopic protein expressions, and transcript assessments. Most strikingly, in both promoters the regions of highest transcriptional activity contain two adjoining, completely identical and conserved Ets1 response elements, and both the mutation of motifs and the overexpression of Ets1 affect significantly transcriptional activity. Also in common are Sp1 response elements that cooperate with Ets1, and Sp1 is phosphorylatable by CK2 holoenzyme but not by individual CK2alpha, the phosphorylation negatively affecting DNA binding." provenance.