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- _4 wasQuotedFrom 10657993 provenance.
- _4 value "To determine the functional importance of this AP-1 site, we used site-directed mutagenesis to generate a 1.4 kb CD44 5'-promoter construct containing an AP-1 site mutation, CD44(-1,262/+109AP-1m). A comparable mutation of the AP-1 motif in the human CD44 promoter (TTAGTCA to CTAGGCA) disrupts the function of this site (53) . In comparison with the native CD44(-1,262/+109) construct, the CD44(-1,262/+109AP-1m) construct displayed a 51% reduction in promoter activity in RASMC after stimulation by IL-1ß " provenance.