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- _4 wasQuotedFrom 10409302 provenance.
- _4 value "AR protein levels, AR activity, sorbitol production, and PKCalpha protein content were also greater in the MCGT1 cells We conclude that increased GLUT1 expression leads to a positive feedback of greater GLUT1 expression, increased AR expression and activity with polyol accumulation, and increased total and active PKCalpha protein levels, which leads to detrimental stimulation of matrix protein synthesis by diabetic mesangial cells." provenance.