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- _4 value "Shn-2-deficient developing Th2 cells showed constitutive activation of nuclear factor kappaB (NF-kappaB) and enhanced GATA3 induction. . . Increased amounts of p65 supershift band were detected after anti-TCR stimulation in Shn-2–/– T cells. Furthermore, an EMSA with anti-p50 antibody revealed that most of the NF-{kappa}B EMSA band detected in nonstimulated Shn-2–/– T cells contained the p50 subunit (Fig. 4 B, lane 11). There was a substantial increase in the level of the p50 band after anti-TCR stimulation (Fig. 4 B, lane 12). These results suggest that NF-{kappa}B is constitutively activated in Shn-2–/– CD4 T cells and it is hyperactivated after anti-TCR stimulation." provenance.