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- _3 wasQuotedFrom 18852255 provenance.
- _3 value "we pre-treated the monocytes with two different antioxidants, DPI (an inhibitor of flavoprotein-containing enzymes such as NADPH/NADPH oxidase) and Tiron (an O2 2 scavenger) to determine the role of reactive oxygen species (ROS). As shown in Figure 4A and B, DPI and Tiron abolished LTB4-induced MAPK pathways activation and NF-kB activation, respectively. These results show that LTB4 regulates MAPK and NF-kB pathways in a ROS-dependent mechanism." provenance.