Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RA3oQnO6-5Van5IXvSvfvpUcahUdCCReR1RBKkgWNWWVQ#_6> ?p ?o ?g. }
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- _6 wasQuotedFrom 17093192 provenance.
- _6 value "We show here in cultured tamarin hepatocytes that GBV-B NS3/4A protease, but not a related catalytically inactive mutant, effectively blocks innate intracellular antiviral responses signaled through the RNA helicase, retinoic acid-inducible gene I (RIG-I), an essential sensor molecule that initiates host defenses against many RNA viruses, including HCV. GBV-B NS3/4A protease specifically cleaves mitochondrial antiviral signaling protein (MAVS; also known as IPS-1/Cardif/VISA) and dislodges it from mitochondria, thereby disrupting its function as a RIG-I adaptor and blocking downstream activation of both interferon regulatory factor 3 and nuclear factor kappa B." provenance.