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- _5 value "Progressive insulin resistance in MKO mice Body weights were similar in control and MKO mice at 6 and 14 months of age (Table 1). Basal glucose levels were measured every two months (data not shown); values were the same among all groups at 6 and 14 months of age (Table 1). Basal insulin levels, measured throughout the lifetime of these animals, were significantly elevated in MKOfl/fl compared with controlfl/fl mice as early as 6 months of age (P = 0.0004). There was a nonsignificant increase in basal levels of free fatty acids (FFA; 20?25%) in both MKO groups, (and these differences were amplified during the glucose clamp study) (see below). Triglyceride levels were significantly elevated in both MKO groups compared with controls (approx1.5-fold; P = 0.001) by 14 months of age (Table 1). At 14 months, the absence of one Pparg allele in the controlfl/- mice caused a significant reduction (33%; P = 0.035) in plasma Acrp-30 (adipocyte complement-related protein, 30 kDa)." provenance.