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- _4 wasQuotedFrom 12533668 provenance.
- _4 value "Recombinant human MDA-7 at a concentration of 20 ng/ml resulted in clear down-regulation of iNOS expression by 48 hours in A375 melanoma cells. Similarly in another experiment, A375 cells were infected with Ad-Mda7 at 1000 and 2000 viral particles per cell which completely down-regulated expression of iNOS by 48 hours. These results prove that MDA-7 gene transfer blocks iNOS expression in melanoma cells." provenance.