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- _4 wasQuotedFrom 17196391 provenance.
- _4 value "Analyses of a panel of fresh brain tumors (Fig. 1AFigure 1, Fig. S1A) demonstrated the ubiquitous and varied expression of HH-GLI pathway components including GLI1, SHH and PTCH1, confirming the general presence of an active pathway (Fig. 1AFigure 1, Figs. S1B, C, S2), as GLI1 transcription is the only reliable marker of pathway activity. .....Here we demonstrate that human gliomas and their cancer stem cells require HH-GLI pathway activity for proliferation, survival, self-renewal and tumorigenicity. " provenance.