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- _4 value "NF-?B also controls expression of other genes, the activities of which are linked to the invasive and metastatic behavior of cancer cells (Fig. 1). For example, NF-?B regulates expression of matrix metalloproteinase-9 (MMP-9), which is responsible for the degradation of tissue barriers [37]; cyclin D1, a cell cycle regulatory protein, which stimulates dysregulation of the cell cycle and tumor formation [38]; cell survival proteins Bcl-2 and BclXL, which protect against apoptosis of cancer cells [39]; and vascular endothelial growth factor (VEGF), which is a potent angiogenic factor stimulating tumor growth [40]. Based on the biological effects of NF-?B?regulated genes in cancer growth, invasion and metastasis, NF-?B has been suggested as a potential target for cancer therapies [41]." provenance.