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- _4 value "Inhibition of NF-?B activation by SN50 (an inhibitor of NF-?B nuclear translocation), MG132 (an inhibitor of ubiquitin-conjugated protein degradation), dnI?B-?, dnp65, dnIKK2, and SC-514 (an inhibitor of IKK2) all attenuated IL-18-mediated PTEN promoter-driven reporter gene activity (Fig. 6A)." provenance.