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- _4 wasQuotedFrom 15668399 provenance.
- _4 value "Forkhead family members FOXO1, FOXO3a, and FOXO4 are multifunctional transcription factors, which regulate transcription of a number of genes that play critical roles in inducing either cell cycle arrest or apoptosis. Activation of each member of this family in transformed and nontransformed cells results in up-regulation of the cyclin-dependent kinase inhibitor p27KIP1 and/or down-regulation of D-type cyclins, thereby arresting cells at G1" provenance.