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- _6 wasQuotedFrom 19570984 provenance.
- _6 value "To test whether the cell proliferation defect observed with Rin1 depletion was because of altered EGFR signaling, A549 cells were transfected with control or Rin1-specific morpholinos, serum-starved, and then stimulated with EGF. The levels of phosphorylated ERK1/2 (pERK) were used to assess EGF signaling (Fig. 2C). Depletion of Rin1 from A549 cells resulted in at least a 2-fold decrease in pERK levels (Fig. 2, C and D), but not total ERK levels (supplemental Fig. 2), indicating that the decrease in cell proliferation correlated with a decrease in EGF signaling." provenance.