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- _7 wasQuotedFrom 16170185 provenance.
- _7 value "The effector domain of GTP-bound Ras binds to C-Raf through the RBD and CRD in the CR1. Although binding to both sites is required for Raf activation, the most critical interaction is between Ras-GTP and the RBD.127 All Ras isoforms are capable of interacting with Raf, but K-Ras is the most potent activator, whereas N-Ras is much more efficient than H-Ras.128 The interaction between Ras and C-Raf alone is insufficient to activate C-Raf, but it serves to translocate C-Raf to the cell membrane where it can be activated." provenance.