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- _5 wasQuotedFrom 12482592 provenance.
- _5 value "Binding of 14-3-3 proteins to phosphoserine residues in the C-terminus of the insulin-like growth factor-1 receptor (IGF-1R) has been described to occur in a variety of cell systems, but the kinase responsible for this serine phosphorylation has not been identified yet. here we present evidence that the isolated dimeric insulin-like growth factor-1 receptor kinase domain (IGFKD) contains a dual specific (i.e. tyrosine-serine) kinase activity that mediates autophosphorylation of C-terminal serine residues in the enzyme.." provenance.