Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RA93E1A6vealjbUnu2ypvpAqT7GC1sLAIqwOsHRR5kVQg#_6> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _6 wasQuotedFrom 16135802 provenance.
- _6 value "\"Smad proteins mediate signaling by transforming growth factor-beta (TGF-beta) 1 superfamily members (1-3). Upon binding of TGF-beta to cell surface complexes of type I and type II receptor serine/threonine kinases, the type II receptor phosphorylates the type I receptor, which further phosphorylates the receptor-regulated (R-) Smads, Smad2 and Smad3 (3). Phosphorylated R-Smads oligomerize with the common mediator (Co) Smad4 and accumulate in the nucleus where they regulate gene expression.\"" provenance.