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- _6 wasQuotedFrom 19601981 provenance.
- _6 value "After binding of leptin to its receptor, the ObRb associated JAK2 becomes activated by auto or cross phosphorylation and it phosphorylates tyrosine residues in the cytoplasmic domain of the receptor, followed by phosphorylation and activation of the signal transducer and activator of transcription (STAT3).....Other adaptor proteins are recruited to activate phosphatidylinositol-3-phosphate kinase (PI3K) and extracellular signal-regulated kinase 1 ? 2 (ERK1 ? 2).......PI3K enhances the activity of phosphodiesterase 3B (PDE3B) which increases AMP formation from cAMP and thereby induces adenosine monophosphate kinase (AMPK)." provenance.