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- _5 wasQuotedFrom 12223121 provenance.
- _5 value "Furthermore, amplification and overexpression of SRC-3 were observed in 10% and 64% of human primary breast cancers, respectively [18]. This observation indicates that SRC-3 is not only essential for the normal mammary development, but also plays a role in breast tumorigenesis It has been demonstrated by transient transfection assay that RPF1 and E6-AP could potentiate the ligand-dependent transcriptional activity of the PR, the glucocorticoid receptor, and other nuclear receptors [19,20]. Furthermore, RPF1 and E6-AP acted synergistically to enhance PR transactivation" provenance.