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- _4 wasQuotedFrom 9892211 provenance.
- _4 value "Incubation of DU-145 cells with IGF-1 (100ng/ml) induced the activity of p42/ERK2. Preincubation of these cells with MAb-EGFR-528 (for one hour) resulted in inhibition of the IGF-1 induced p42/ERK2 activity. This suggests that IGF-1 activate the ERK pathway via the involvement of the EGF receptor. p42/ERK2 activity induced by IGF-1 was also observed in LNCaP cells." provenance.