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- _4 wasQuotedFrom 9664071 provenance.
- _4 value "Fibroblast like synoviocytes were incubated with TNF-alpha(10ng/ml). TNF-alpha induced an hsp70 response, resulting in transcriptional activation of HSF1 and enhanced hsp70 protein expression. TNF-alpha treated cells showed the formation of the hyperphosphorylated higher molecular weight isoform of HSF1. Activation of HSF1 by TNF-alpha was dose-dependent between 5 and 15 ng/ml of cytokine added to the cultures. Time kinetics revealed maximum DNA binding activity of HSF1 after 3hours of cytokine incubation." provenance.