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- _6 wasQuotedFrom 16135802 provenance.
- _6 value "\"Smad proteins mediate signaling by transforming growth factor-beta (TGF-beta) 1 superfamily members (1-3). Upon binding of TGF-beta to cell surface complexes of type I and type II receptor serine/threonine kinases, the type II receptor phosphorylates the type I receptor, which further phosphorylates the receptor-regulated (R-) Smads, Smad2 and Smad3 (3). Phosphorylated R-Smads oligomerize with the common mediator (Co) Smad4 and accumulate in the nucleus where they regulate gene expression.\"" provenance.