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- _5 wasQuotedFrom 16880517 provenance.
- _5 value "The three major phosphatidylinositol 3-kinase-like kinases ATM, ATR, and DNA-dependent protein kinase have the ability to phosphorylate the C-terminal tail of the histone variant H2AX on serine 139. Whereas this phosphorylation is carried out exclusively by ATM or DNA-dependent protein kinase after ionizing irradiation (38), ATR is responsible for the reaction in response to replication stress (44)" provenance.