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- _4 wasQuotedFrom 19351856 provenance.
- _4 value "Chromatin immunoprecipitation analysis (Fig. 3B) revealed a dose-dependent increase in H3K27me3, which coincided with recruitment of EZH2 and SUZ12 (components of the “initiation” polycomb repressor complex 2 that catalyze H3K27me3), as well as Bmi1, a member of “maintenance” polycomb repressor complex 1 (27). Additional analysis confirmed the dose-dependent deacetylation of H4K16, which coincided with recruitment of SirT1, a class III histone deacetylase that mediates H4K16deacet ylation (28)." provenance.