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- _3 wasQuotedFrom 15294054 provenance.
- _3 value "This concept is illustrated by the results of studies utilizing diabetic rats in which animals engaged in resistance exercise (Farrell et al. 1999; Fedele et al. 2000; Kostyak et al. 2001). In such studies rats are operantly conditioned to touch an illuminated bar high on a Plexiglas exercise cage while wearing a weighted vest strapped over the scapulae (Fluckey et al. 1995). The movement performed during the exercise requires the animals to complete concentric and eccentric muscle contractions of the hindlimb musculature (Fluckey et al. 1995). While moderatelydiabetic animals (fed arterial insulin, approximately 180 pM) exhibit an increase in protein synthesis rate as well as augmented eIF2B activity post-exercise, severely-diabetic (fed arterial insulin, approximately 72 pM) animals exhibit depressed protein synthesis rates and eIF2B activity at rest, which fails to change with subsequent exercise (Farrell et al. 1999; Fedele et al. 2000; Kostyak et al. 2001)." provenance.