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- _7 value "from full text - In BE cells transfected with b-arrestin1 siRNA no pERK signals were detected (Fig. 1, C and D). These data provide further evidence that b-arrestin1 is necessary for IGF-1-induced ERK activation. We also investigated whether b-arrestin2 played a similar role. However, no significant reduction in IGF-1-stimulated pERK was observed in BE cells transfected with b-arrestin2 siRNA (Fig. 1, C and D). In contrast, down-regulation of b-arrestin2 levels led to an increase in both basal and IGF-1-stimulated ERK activity that was sustained up to 60 min (Fig. 1, C and D)." provenance.