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- _7 value "To investigate the potential interaction of Tiam1, HER2, and beta -catenin, cell lysates were immunoprecipitated with an anti-HER2 antibody, and the precipitated material was immunoblotted with different antibodies. We found no evidence of an association of Tiam1 with HER2 receptors (Fig. 2B). In contrast, there was a significant increase in the content of beta -catenin associated with activated HER2 receptor (Fig. 2B)." provenance.