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- _4 wasQuotedFrom 17681183 provenance.
- _4 value "miR-21 was noted to be highly overexpressed in HCC tumors and cell lines in expression profiling studies using a miRNA microarray. Inhibition of miR-21 in cultured HCC cells increased expression of the phosphatase and tensin homolog (PTEN) tumor suppressor, and decreased tumor cell proliferation, migration, and invasion. In contrast-enhanced miR-21 expression by transfection with precursor miR-21 increased tumor cell proliferation, migration, and invasion. PTEN was shown to be a direct target of miR-21, and to contribute to miR-21 effects on cell invasion. " provenance.