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- _4 wasQuotedFrom 19183745 provenance.
- _4 value "Once sequestrated into tissues, circulating renin and prorenin not only enhance local Ang II synthesis, but also directly trigger Ang-II independent reactions which might be potentially active on the development of atherosclerotic plaque (Nguyen 2006; Oliver 2006). These reactions include: a) Activation of intracellular kinases. b) Stimulation of DNA synthesis. c) Increased release of plasminogen activator inhibitor (PAI-1) and transforming growth factor (TGF)-? (Ichihara et al 2006; Nguyen and Danser 2006)." provenance.