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- _6 wasQuotedFrom 12893815 provenance.
- _6 value "Although the kinase activity of IRAK-1 increases strongly following IL-1 stimulation, IRAK-1 kinase activity is not required for its signaling function, because overexpression of a kinase-defective mutant of IRAK-1 is observed to strongly induce NF-κB activation in cells otherwise deficient for IRAK-1. Upon stimulation, IRAK-1 is recruited to the receptor through a homophilic interaction with the DD of MyD88." provenance.