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- _2 value "BAT is activated in vivo under particular circumstances such as cold exposure, high fat diet feeding and during the perinatal period as a defend mechanism against cold or obesity. Acute activation of BAT thermogenesis appears to be mediated by noradrenaline liberated from the sympathetic nervous system. By acting through b-receptors, noradrenaline increases intracellular cAMP levels, which in turn activate lipolysis." provenance.