Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAFxZ0J8RuWxb6WCaeJY_T3WYBb7nBFy1VoXKWaTNz_cQ#_5> ?p ?o ?g. }
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- _5 wasQuotedFrom 12746450 provenance.
- _5 value "Here we investigate the molecular mechanisms underlying met oncogenic conversion by generating antibodies specific for the differently phosphorylated forms of the Met protein. Using these antibodies, we show that activation of wild-type Met is achieved through sequential phosphorylation of Tyr1235 and Tyr1234 in the activation loop and that mutagenesis of either tyrosine dramatically impairs kinase function. " provenance.