Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAG74LlmwG1bKr2ZEr9xnQHF6cFXw3ykn_YLGjApTDC2I#_7> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _7 wasQuotedFrom 15456867 provenance.
- _7 value "In summary, we have found the following: (i) beta-arrestin-1 can alter insulin signaling by inhibiting insulin-induced proteasomal degradation of IRS-1; (ii) beta-arrestin-1 decreases the rate of ubiquitination of IRS-1 by competitively binding to endogenous Mdm2, an E3 ligase that can ubiquitinate IRS-1; (iii) dephosphorylation of S412 on beta-arrestin and the amino terminus of beta-arrestin-1 are required for this effect of beta-arrestin on IRS-1 degradation; and (iv) inhibition of beta-arrestin-1 leads to enhanced IRS-1 degradation and accentuated cellular insulin resistance." provenance.