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- _4 wasQuotedFrom 18794886 provenance.
- _4 value "Although previous studies had shown that the consequence of functional loss of the TSC complex on PI3K was prevented by rapamycin (Harrington et al., 2004), it was not until 2006 that the group of Dr Rosen demonstrated that rapamycin treatment induced AKTactivatio n in cancer patients, a strong drawback for the use of this family of inhibitors as single agent in the clinic (O’Reilly et al., 2006)." provenance.