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- _4 wasQuotedFrom 14610276 provenance.
- _4 value "In lean mice and db/db mice, injection of insulin produced rapid tyrosine phosphorylation of insulin receptor substrate 1 (IRS-1), recruitment of p85, the regulatory subunit of phosphatidylinositol 3-kinase and phosphorylation of the downstream signaling molecule Akt. CNTF (0.1 mg/kg per day or 0.3 mg/kg per day) treatment increased hepatic insulin sensitivity as evidenced by the robust phosphorylation of IRS-1. However, food restriction alone failed to improve hepatic insulin sensitivity." provenance.