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- _6 wasQuotedFrom 14517341 provenance.
- _6 value "PLD1 is activated by the ADP ribosylation factor (ARF)-, Ral-, and Rho-family GTPases, as well as by protein kinase C a (PKC-a; 5). Both PLD1 and PLD2 have an absolute requirement for PI-4,5-bis-phosphate (PIP2; 19, 21). PLD2 activity is elevated by fatty acids (21). PLD2 is constitutively active in vitro and this activity is unaffected by GTPases or PKC-a" provenance.