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- _4 wasQuotedFrom 12529413 provenance.
- _4 value "Blockage of MAPK activation by preincubation with PD98059 resulted in the complete abolishment of the HRG capacity to phosphorylate Ser249. However by the invitro studies carried out, it was found that MAPK activated by the HRG were able to induce strong phosphorylation of both Progesterone Receptor A and Progesterone Receptor B. Further evidence of MAPK direct involvement in progesterone receptor (PR) phosphorylation is provided by the finding that when MAPKs immunoprecipitated from cells in which their HRG induced activation of had been abolished by PD98059, no phosphorylation of PR was observed." provenance.