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- _3 wasQuotedFrom 20847132 provenance.
- _3 value "Human myofibroblasts turned to hypoxia-driven gene expression, indicated by VEGF expression, at oxygen concentrations of 4% and lower. Gene expression levels of procollagen alpha1(I) and alpha1(III) increased to 138??26% and 143??19% respectively, for all oxygen concentrations below 4%. At 2% O(2), LH2 and LOX gene expression levels were higher than control cultures (340??53% and 136??29% respectively) and these levels increased even further with decreasing oxygen concentrations (611??176% and 228??45% at 0.5% O(2) respectively). Elastin gene expression levels remained unaffected. Collagen synthesis and LH2 protein levels increased at oxygen concentrations of 2% and lower. Oxygen concentrations below 4% induce enhanced ECM production by human myofibroblasts." provenance.