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- _8 wasQuotedFrom 12110143 provenance.
- _8 value "PIAS proteins constitute a family (PIAS-1, PIAS-3, PIAS-Xalpha, PIAS-Xbeta, and PIAS-Y) of constitutively expressed negative regulators of STATs Pias1 associates only with activated STAT1 dimers and inhibits their DNA-binding activity Pias3 associates specifically with activated STAT3 but not with STAT1, resulting in the blocking of all STAT3-mediated gene transcriptions Pias3 is especially well known as an inhibitor of Il6 signaling in M1 cell lines" provenance.